Therapy Tag's Archives
Synopsis of Important Principles
- Critical illnesses are often associated with circulatory, respiratory, hepatic and/or renal dysfunction that may alter the pharmacokinetics and/or pharmacodynamics of drugs.
- Decisions about routes of administration and doses of drugs used during medical emergencies must consider the physiological status of the patient, the pharmacokinetic and pharmacodynamic characteristics of the particular drug, and how the two interact.
- Adverse drug reactions and interactions are more likely in critically ill patients due to the effect of the disease on drug kinetics, the decreased toxic-therapeutic ratio due to severe underlying illness, and the large number of medications that such patients receive. Adverse reactions to drugs should be considered when unexplained deterioration or failure to respond to therapy are encountered.
Blood, Critical Care, Critical Illness, Disease, Dosage, Drug, Effect, Glucose, Hypertension, Infection, Medical Emergencies, Medication, Respiratory, Syndrome, Therapeutic, Therapy, Toxic, Treatment
General Anaesthetic Agents
The mechanism by which anaesthetic drugs produce unconsciousness is still unknown. Meyer in 1899 and Overton in 1901 noted that within any group of drugs, anaesthetic potency correlates well with lipid solubility, and most modern theories agree that the site of action is probably the lipid bilayer of nerve cell membranes, or possibly a protein receptor in this situation, but further knowledge is limited.
Inhalational Agents
Anaesthetic practice is unique in that a high proportion of the drugs are administered by the inhalational route. Such agents must either be gaseous, or the vapour of volatile liquids (Various Authors 1984).
Of the original three inhalational agents – nitrous oxide, ether and chloroform – the first two are still used widely.
Anaesthetic, Blood, Cardiac, Coefficient, Drug, Effect, Muscle, Potency, Side Effects, Soluble, Therapy, Treatment
Synopsis of Important Principles
- The main aim of anaesthesia is the prevention of pain during surgery and at other times.
- Anaesthesia involves a balanced approach, in which the individual patient’s psyche and pathophysiology are taken into account and drugs are used to modify and control any aspect as required.
- The decision to use a particular drug or technique must be made after careful consideration of the pathophysiological features of the individual case and how these may affect the pharmacokinetic handling and tissue response to the drugs available.
- Any associated disease or pathophysiological abnormality should wherever possible be treated or corrected before operation, and potentially dangerous physiological disturbances avoided during and after anaesthesia.
- Anaesthetic drugs are relatively non-toxic but there are some important effects. Halothane is occasionally associated with hepatitis and methoxyflurane with kidney damage. Malignant hyperpyrexia, the aetiology of which is uncertain, is a rare but often fatal condition which can be triggered off by several anaesthetic drugs in genetically susceptible individuals.
Anaesthesia, Chronic Pain, Clinical, Disease, Dosage, Effect, Electrolyte, Kidney, Method, Oral, Pain, Respiratory, Risk, Severe, Surgery, Surgical, Therapy, Treatment
A Benzodiazepine sedative class type of dug , Clorazepate is generic drug name for Gen-Xene, Tranxene, Tranxene-SD , Tranxene T-Tab. It is commonly prescribe for treating several conditions :-
- Anxiety,
- tension,
- symptoms of acute alcohol withdrawal,
- partial seizures,
- fatigue,
- agitation,
- irritable bowel syndrome,
- and panic attacks.
General Information of the drug
- Clorazepate dipotassium is a benzodiazepine, which directly affect the brain. This drug is a central-nervous-system depressant, and can relax you and make you more tranquil or sleepier, or they can slow nervous system transmissions in such a way as to act as an anticonvulsant.
Alcohol, Allergic, Anxiety, Blood, Bloodstream, Brain, Condition, Confusion, Disease, Disturbances, Dosage, Drowsiness, Drug, Effect, Fatigue, Heart, Kidney, Liver, Mental, Muscle, Nervous, Risk, Sensitivity, Side Effects, Symptoms, Tension, Therapy, Toxic, Transmission, Treatment, Tremor, Unusual
Synopsis of Important Principles
1. Specific antidotal therapy is available for very few poisons. The mainstay of treatment of severe poisoning is intensive supportive therapy and good nursing care.
2. The great majority of poisoned patients recover with intensive supportive therapy alone, and enthusiastic claims for the success of other treatment often cannot be justified.
3. With some important exceptions, the management of poisoning is not altered by knowledge of plasma drug concentrations. There are many pitfalls in the interpretation of drug concentrations in poisoned patients, especially when nonspecific analytical methods are used.
Antidotal, Blood, Care, Circulation, Concentration, Dialysis, Diffuse, Dosage, Dose, Drug, Effect, Indication, Inhibition, Intensive, Mechanism, Metabolic, Method, Mortality, Nursing, Overdose, Pharma, Plasma, Poison, Specific, Support, Synopsis, Technique, Therapy, Toxic, Treatment, Volume
