Synopsis of Important Principles Critical illnesses are often associated with circulatory, respiratory, hepatic and/or renal dysfunction that may alter the pharmacokinetics and/or pharmacodynamics of drugs. Decisions about routes of administration and doses of drugs used during medical emergencies must consider the physiological status of the patient, the pharmacokinetic and pharmacodynamic characteristics of the particular drug, [...]
Haemodialysis, peritoneal dialysis, haemoperfusion, exchange transfusion and forced diuresis have all been used in attempts to increase the rate of removal of drugs and poisons. However, the amount of active drug removed is often disappointingly small, and the indications for the use of such measures is very limited. Nevertheless, poisoned patients are often unnecessarily subjected [...]
A Benzodiazepine sedative class type of dug , Clorazepate is generic drug name for Gen-Xene, Tranxene, Tranxene-SD , Tranxene T-Tab. It is commonly prescribe for treating several conditions :- Anxiety, tension, symptoms of acute alcohol withdrawal, partial seizures, fatigue, agitation, irritable bowel syndrome, and panic attacks. General Information of the drug Clorazepate dipotassium is a benzodiazepine, [...]
Gastric Aspiration and Lavage Although unabsorbed drug in the stomach may be removed by gastric aspiration and lavage its usefulness in practice has been seriously questioned (Proudfoot 1984). Most drugs and poisons seem to be absorbed rapidly and this technique is unlikely to be productive more than 4 hours after ingestion, unless gastric emptying has [...]
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