Value Tag's Archives
The idea that drug concentrations could be measured and used to guide therapeutic decisions was first applied to quinidine when it was used to convert the cardiac rhythm of patients with atrial fibrillation to sinus rhythm (Sokolow & Ball 1956).
Although quinidine is rarely used for this purpose today, because of the advent of DC cardioversion, this study is still almost unique because it defined a target concentration based upon both the probability of therapeutic success and of toxicity.
Data, Distribution, Dose, Drug, Effect, Foundation, Monitoring, Rational, Science, Selection, Sensitivity, Studies, Therapeutic, Toxicity, Value
Therapeutic drug monitoring is based upon the collaboration between a health care provider (clinician, pharmacist, nurse) responsible for making quantitative and qualitative decisions about drug treatment and the clinical laboratory providing analytical services for the measurement of drug concentrations. The information provided by a drug concentration measurement is generally greater than for other substances measured by the laboratory.
This is because, unlike say sodium or glucose, the intake of a drug is quite well known and the processes of distribution and elimination are usually very simple and not under the control of a multitude of homeostatic controlling reflexes.
Analytical, Clinical, Collaboration, Diagnose, Dosage, Dose, Drug, Figures, Forecasting, Glucose, Interval, Laboratory, Measurement, Multitude, Precision, Provider, Quantitative, Rational, Reference, Serum, Substance, Substitute, Therapeutic, Treatment, Value
